According to Lock and Key model, the active site is regarded as:

  • A. Rigid and specific
  • B. Flexible and specific
  • C. Rigid and non specific
  • D. Flexible and non specific

Explanation

Fischer's lock and key model treats the active site as a pre formed rigid shape that only the matching substrate fits, which explains specificity but not the conformational changes later observed. Koshland's induced fit model keeps the specificity but makes the site flexible, moulding itself around the substrate as it binds. Both models agree that the enzyme is specific.

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