Chargaff's rules state that in any DNA molecule

  • A. adenine equals guanine and cytosine equals thymine
  • B. the amount of adenine is always greater than that of thymine
  • C. the amount of adenine equals thymine and guanine equals cytosine
  • D. purines are always more numerous than pyrimidines

Explanation

Because A pairs with T and G pairs with C across the helix, their amounts must match in any double stranded DNA. Pairing A with G instead would ignore the actual hydrogen bonding partners, and purines equal rather than outnumber pyrimidines.

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