In an aqueous environment the most stable tertiary conformation is that in which _________ amino acids are buried inside the conformation?

Correct answer: A. Hydrophobic

  • A. Hydrophobic
  • B. Hydrophilic
  • C. Basic
  • D. None of these

Explanation

In water, hydrophobic side chains tend to avoid contact with water and become buried in the interior of a folded protein. Hydrophilic and charged side chains are more likely to remain exposed, where they can interact with water. Students may choose b because hydrophilic amino acids interact well with water, but that is precisely why they are usually exposed rather than buried.

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