In an aqueous environment the most stable tertiary conformation is that in which _________ amino acids are buried inside the conformation?
Correct answer: A. Hydrophobic
- A. Hydrophobic
- B. Hydrophilic
- C. Basic
- D. None of these
Explanation
In water, hydrophobic side chains tend to avoid contact with water and become buried in the interior of a folded protein. Hydrophilic and charged side chains are more likely to remain exposed, where they can interact with water. Students may choose b because hydrophilic amino acids interact well with water, but that is precisely why they are usually exposed rather than buried.
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