In Citric Acid Cycle Acetyl CoA combines with:

Explanation

In the citric acid cycle (also known as the Krebs cycle or tricarboxylic acid cycle), acetyl-CoA combines with oxaloacetate to initiate the cycle. This condensation reaction is catalyzed by the enzyme citrate synthase. This reaction marks the beginning of the citric acid cycle. Citrate is a six-carbon compound, and as it undergoes a series of reactions, carbon atoms are released as carbon dioxide, and high-energy electrons are transferred to carrier molecules NADH and FADH2. The cycle ultimately regenerates oxaloacetate, which can combine with another molecule of acetyl-CoA to continue the cycle. The citric acid cycle is a key component of cellular respiration, generating NADH, FADH2, and ATP.